Figure 4
Identification of the oncogenes and TSGs. (A) Twenty-one overlapping genes of the methylation-regulated downregulated genes and oncogenes (left), and fifteen overlapping genes of the methylation-regulated upregulated genes and TSGs (right) are shown. (B) Heatmap showing scaled expression of the oncogenes and TSGs. (C) The PPI network of oncogenes and TSGs. The red spots represent the oncogenes, and the green spots represent the TSGs. (D) and (E) KEGG enrichment analysis (D) and GAD disease analysis (E) of the oncogenes and TSGs. (F) qRT‒PCR validation of the oncogenes and TSGs. Red represents the oncogenes, and green represents the TSGs. (G) A visual summary shows the genetic alteration of the TSGs in breast cancer patients using data from the cBio Cancer Genomics Portal (http://www.cbioportal.org/).
