Figure 11 | Scientific Reports

Figure 11

From: Renogrit selectively protects against cisplatin-induced injury in human renal tubular cells and in Caenorhabditis elegans by harmonizing apoptosis and mitophagy

Figure 11

Renogrit decreased cisplatin-induced oxidative stress and mitochondrial aberrations in C. elegans. (a) Representative images of cisplatin (40 µg/ml) exposed CL2166 (GST-4::GFP) and SJ4058 (HSP-60::GFP) strains of C. elegans showing a decrease in GST-4 and increase in HSP-60 expression respectively. Renogrit (10–100 µg/ml) or NAC (4 mM) treatment normalized the expression of GST-4 and HSP-60 as observed from their respective GFP signals. (b) Graph quantifying the relative intensity of GST-4::GFP signal of the treated and untreated worms from their respective images. (c) Plate-based quantification of HSP-60::GFP signal intensity in SJ4058 worms after exposure with cisplatin (40 µg/ml) in presence of Renogrit (10–100 µg/ml) or NAC (4 mM). Data represented as mean ± S.E.M. ***p < 0.001; ##p < 0.01.

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