Figure 12 | Scientific Reports

Figure 12

From: Renogrit selectively protects against cisplatin-induced injury in human renal tubular cells and in Caenorhabditis elegans by harmonizing apoptosis and mitophagy

Figure 12

Renogrit modulated cisplatin-induced mitophagy and apoptosis. (a) Representative images of LysoView 633 (red) stained C. elegans (N2 strain) induced with cisplatin (40 µg/ml) and treated with Renogrit (100 µg/ml) or NAC (4 mM). Renogrit treatment enhanced the lysosome number that were decreased due to cisplatin exposure in the nematodes. Renogrit treated C. elegans (N2 strain) showed increase in mRNA expression of (b) PINK1, (c) PDR1 genes involved in mitophagy and decrease in pro-apoptotic (d) EGL1 mRNA expression. Data represented as mean ± S.E.M. ### and ***p < 0.001; **p < 0.01; *p < 0.05.

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