Figure 8 | Scientific Reports

Figure 8

From: LncRNA GHET1 from bone mesenchymal stem cell–derived exosomes improves doxorubicin-induced pyroptosis of cardiomyocytes by mediating NLRP3

Figure 8

A scheme of the proposed mechanisms. The expression of lncRNA GHET1 in BMSCs is regulated by the acetylation of its upstream promoter sequence H3K27. Exosome released by BMSCs containing lncGHET1 enters cardiomyocytes. lncGHET1 downregulates NLRP3 expression through decreasing mRNA stability via bind with IGF2BP1, resulting in the inhibition of pyroptosis.

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