Fig. 3

Maximum likelihood protein phylogeny of neurexin-1 homologues from various representative animals. Names of species and genes are colour-coded according to phylum. To the right of the phylogenetic tree is an alignment of the extreme C-terminal sequences of the proteins, illustrating deep conservation of the Mint PDZ-1 ligand motif. The lengths of the neurexin-1 homologues are indicated with black bars, and protein domains predicted with InterProScan are illustrated (LNS: laminin, neurexin, sex-hormone binding globulin ___domain; EGFL: epidermal growth factor-like ___domain; FN3: fibronectin type III ___domain; WD40: tryptophan-aspartic acid 40 repeat ___domain). Node support values generated with SH-aLRT, UFBoot2, and aBayes are indicated by symbols according to the provided legend.