Fig. 2
From: Blood based metabolic markers of glioma from pre-diagnosis to surgery
Metabolite levels in plasma from pre-diagnostic glioma cases compared to controls. (a) Volcano plot of all 134 metabolites and 22 unidentified molecular features for case–control pairs in the NSHDS discovery cohort within eight years before diagnosis (n = 126 pairs). Effect sizes are shown as log2 fold change, and statistical significance by -log10 P-value for individual metabolites using model loadings w. Metabolites with significantly higher (blue) or lower (red) levels in plasma from pre-diagnostic glioma cases are named. (b) Paired-boxplots of the significant metabolites displayed in (a).
