Table 2 Logistic regression model for successful founder production conditional on biological factors annotated for a gene.

From: Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines

Variable

Without essentiality

With essentiality

Odds Ratio

p-value

adjusted

p-value

Odds Ratio

p-value

adjusted

p-value

(Intercept)

11.97

2.0 × 10–16

2.7 × 10–19

12.09

2.22 × 10–16

5.3 × 10–19

Essential

NA

NA

NA

0.41

1.23 × 10–9

1.11 × 10–8

Embryonic expression

0.57

0.010

0.081

0.74

0.199

1.00

pLI score

0.74

0.126

0.867

0.78

0.218

1.00

o/e score

1.00

0.992

1.00

0.97

0.910

1.00

Chromosome position

1.10

0.640

1.00

1.09

0.658

1.00

Acetylated gene

0.86

0.229

1.00

0.91

0.472

1.00

Methylated gene

1.37

0.124

0.866

1.21

0.341

1.00

Giemsa positive stain

1.01

0.926

1.00

1.01

0.901

1.00

OMIM annotation

0.87

0.397

1.00

0.81

0.203

1.00

Observations: 3209

      
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