Fig. 3 | Scientific Reports

Fig. 3

From: Exploring the progression of drug dependence in a methamphetamine self-administration rat model through targeted and non-targeted metabolomics analyses

Fig. 3Fig. 3Fig. 3

Box plots of the target metabolites in plasma collected from methamphetamine self-administering rats at different stages of drug dependence progression. (A) Acylcarnitine. (B) Amino acids and biogenic amines. (C) Glycerophospholipids. (D) Sphingolipids. (E) TCA intermediates. Statistical analyses were performed using the Student’s t-test and normalized values of all the experimental groups were determined using the normalized log2 transformed and median normalized data (fold change > 1.2). The box plots were generated using GraphPad Prism 8. *p < 0.05, **p < 0.01, ***p < 0.001. TCA, tricarboxylic acid.

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