Fig. 5
From: Pan-cancer analysis of the prognostic and immunological roles of SHP-1/ptpn6
The ptpn6-related genes/proteins enrichment analysis. (A) The available experimentally determined SHP-1-binding proteins from the STRING database and their interaction network. (B) The correlation of the expression between ptpn6 and the top five ptpn6-related genes, including WAS, ARHGAP30, ARHGAP9, CORO1A and RAC2 (R = 0.76, 0.75, 0.74, 0.74, 0.74). (C) The corresponding heatmap between these five genes and ptpn6 in the 33 types of cancer. The significant threshold was set as p < 0.05. Red indicates a positive correlation, while blue means the opposite. The darker the color is, the closer the absolute value of the correlation coefficient is to 1, and the higher the correlation is. (D,E) KEGG pathway analysis and GO enrichment analysis for the SHP-1-binding proteins and ptpn6-related genes.
