Fig. 8
(a) Effect of T-cell immunogenicity on IgG induction. k3 and k10 are assigned to a smaller number (1.5) for the low T-cell immunogenicity group. They are assigned to a larger number (2.5) for its strong T-cell immunogenicity counterpart. (b) An illustration of approaches in improving Th-cell immonogenity. Two stragties are presented : rational design of antigen with conserved epitope structure and the design of polymer antigen with strong T-cell immonogenity segments.
