Fig. 1

Flowchart of the multistep screening and verification strategy on bioinformatics data and in vitro experiment. CTEPH chronic thromboembolic pulmonary hypertension, DEGs differentially expressed genes, WGCNA weighted gene co-expression network analysis, PPI network protein–protein interaction network, LASSO least absolute shrinkage and selection operator, SVM-RFE support vector machine recursive feature elimination, qRT-PCR quantitative reverse transcription polymerase chain reaction.