Figure 3
Necdin affects mRNA export by regulating THOC5. (a) Gene expression in the nuclear from VTA of WT and KO mice as assayed by RNA-Seq. (b) KEGG pathway analysis on differentially expressed genes. (c) Volcano plot depicting the relative mRNA abundance in the nuclear from VTA of KO mice compared with WT controls. Upregulated synaptic development and related signaling pathways are indicated. (d) qPCR quantification of DA neuronal development-related genes and THOC5 target genes, and control transcripts in WT and KO mice. Data were mean ± SEM, n = 6, *p < 0.05, **p < 0.01, unpaired t-test.
