Figure 2 | Scientific Reports

Figure 2

From: CXCL12/CXCR4 pathway as a novel therapeutic target for RNF213-associated pulmonary arterial hypertension

Figure 2

Gene expression is regulated by the RNF213+/p.Arg4828Lys variant. The mRNA expressions of RNF213+/p.Arg4828Lys mice fed in hypoxia conditions were compared with those of RNF213+/+ mice fed in hypoxia conditions. (a) Volcano plots. Red dots indicate significantly upregulated genes and green dots indicate significantly downregulated genes in RNF213+/p.Arg4828Lys mice. (b) Heat-map analysis. (c) Top 15 genes that were up or downregulated in RNF213+/p.Arg4828Lys mice. (d) Protein-protein network analysis. (e) Gene ontology analysis.

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