Fig. 1
Downregulation of ACSL1 Contributes to Mitophagy in IPF. (A) The volcano plot based on the GSE134692 dataset, with adjusted P value < 0.05 and |log2(fold change)| > 1. (B) The volcano plot based on the GSE32537 dataset, with adjusted P value < 0.05 and |log2(fold change)| > 1. (C) The Venn plot showing ACSL1 as the only gene intersection among the GSE134692 dataset, GSE32537 dataset, autophagy-related genes, and mitochondrial-related genes. (D) ACSL1 expression in IPF patients (n = 46) and controls (n = 26) based on the GSE134692 dataset. (E) ACSL1 expression in IPF patients (n = 119) and controls (n = 50) based on the GSE32537 dataset. (F) The scatter diagram shows a negative correlation between the expression of ACSL1 and St. George’s total score in IPF patients based on the GSE32537 dataset. (G) The scatter diagram shows a negative correlation between the expression of ACSL1 and FVC pre-bronchodilator % predicted in IPF patients based on the GSE32537 dataset. (H) The scatter diagram shows a negative correlation between the expression of ACSL1 and DLCO % predicted in IPF patients based on the GSE32537 dataset. Abbreviations: ACSL1, long-chain fatty acyl-CoA synthetase 1; DLCO % predicted, percent predicted diffusion capacity of the lung for carbon monoxide; GSE, Gene Expression Omnibus Series; FVC pre-bronchodilator % predicted, percent predicted forced vital capacity; IPF, idiopathic pulmonary fibrosis. Data are expressed as mean ± SEM. *** P < 0.001.
