Fig. 5
From: The deleterious effects of CDK4/6 inhibition on renal recovery post-acute kidney injury
Palbociclib increases the renal fibrosis reduced by D + Q in uIRI murine model. Immunoblot analyses illustrating representative blots and quantitative data for α-SMA and Collagen I in renal tissue are shown (A-C). Representative blots are presented (A), with quantification of α-SMA and Collagen I level shown in (B) and (C), respectively. Representative immunohistochemical staining of Sirius Red, α-SMA, Collagen I, and Fibronectin in renal tissue (scale bar, 50 μm) is depicted (D). Semi-quantitative analysis of stained renal tissue sections, indicating the positive areas for Sirius Red (E), α-SMA (F), Collagen I (G), and Fibronectin (H), is provided. The qPCR and immunoblot results are shown as the fold change compared with the Sham group. Data are expressed as mean ± SD. n = 4 for the Sham group and n = 6 for all other groups. *p < 0.05, **p < 0.01, ***p < 0.001.
