Fig. 1

(a) MRE experimental setup. Two pressurized air pads placed underneath the head of the subject induce vibrations in the brain. (b) THE and optical tracking experimental setup. Fiducial markers (spheres) are attached to the head, a stylus, and the ultrasound probe. First, the optical tracking system is calibrated by pointing the stylus at previously chosen anatomical landmarks. Next, THE is performed by vibrating the head of the subject using a patient bed with an integrated speaker. During the THE examination, the ultrasound probe is positioned at the right temples of the subject and the exact position is recorded by the camera and projected onto the rendered and localized T1-weighted MRI map, thus enabling a neuronavigation display. (c) Resulting alignment of the FoVs of MRE (blue) and THE (green). 3D render (upper left corner) and 2D projections onto a T1-weighted MRI map (upper right: coronal view, lower left: sagittal view, lower right: axial view) are included. Written informed consent for publication of their clinical images was obtained from the subject. A copy of the consent form is available for review by the Editor of this journal.