Fig. 8 | Scientific Reports

Fig. 8

From: Hypoxia-induced TPC2 transcription and glycosylation aggravates pulmonary arterial hypertension by blocking autophagy flux

Fig. 8

Baf A1 administration showed no significant effects on PAH rats. SD rats were divided into Control, PAH, PAH + rapa, PAH + Baf A1, PAH + GNGnase and PAH + ned19 groups (n = 5). (A) H&E staining of pulmonary aorta and the lung. (B) The expression of α-SMA, LC3 and p62 was detected via IHC staining. (C) TEM examination of autophagy. Scale bar, 500 nm. (D) Western blot analysis of TPC2 and its glycosylation. *P < 0.05, **P < 0.01 and ***P < 0.001. Original blots/gels are presented in Supplementary Fig. 4–8.

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