Table 2 Content of autophagy-related proteins in the mouse airways (\(\overline{{\varvec{x}}}\pm \mathbf{s }\), n = 6).

From: IL-17A regulates airway remodelling in COPD through the PI3K/AKT/mTOR pathway

Groups

Ad-LacZ

Ad-LacZ+3MA

Ad-IL-1β

Ad-IL-1β+3MA

P62/GAPDH

0.49 ± 0.14

0.84 ± 0.19*

0.87 ± 0.16*

1.30 ± 0.22*

Beclin-1/GAPDH

1.20 ± 0.20

0.46 ± 0.05*

0.39 ± 0.07*

0.33 ± 0.16*

LC3II/LC3I

1.53 ± 0.36

1.18 ± 0.27*

0.96 ± 0.10*

0.32 ± 0.11*

Expression rate of LC3II

1.37 ± 0.28

0.76 ± 0.21*

0.72 ± 0.16*

0.69 ± 0.20*

AP

9.80 ± 1.79

5.20 ± 1.30*

4.60 ± 1.52*

3.60 ± 1.14*

p-PI3K/ PI3K

0.68 ± 0.15

0.97 ± 0.18*

1.17 ± 0.19*#

1.31 ± 0.10*#

p-AKT/AKT

0.57 ± 0.08

0.93 ± 0.07*

1.11 ± 0.12*#

1.62 ± 0.24*#

p-mTOR/mTOR

0.65 ± 0.13

1.47 ± 0.28*

1.84 ± 0.13*#

2.05 ± 0.42*#

  1. *P < 0.05 compared with Ad-LacZ group, #P < 0.05 compared with Ad-LacZ+3MA group.