Table 2 Content of autophagy-related proteins in the mouse airways (\(\overline{{\varvec{x}}}\pm \mathbf{s }\), n = 6).
From: IL-17A regulates airway remodelling in COPD through the PI3K/AKT/mTOR pathway
Groups | Ad-LacZ | Ad-LacZ+3MA | Ad-IL-1β | Ad-IL-1β+3MA |
---|---|---|---|---|
P62/GAPDH | 0.49 ± 0.14 | 0.84 ± 0.19* | 0.87 ± 0.16* | 1.30 ± 0.22* |
Beclin-1/GAPDH | 1.20 ± 0.20 | 0.46 ± 0.05* | 0.39 ± 0.07* | 0.33 ± 0.16* |
LC3II/LC3I | 1.53 ± 0.36 | 1.18 ± 0.27* | 0.96 ± 0.10* | 0.32 ± 0.11* |
Expression rate of LC3II | 1.37 ± 0.28 | 0.76 ± 0.21* | 0.72 ± 0.16* | 0.69 ± 0.20* |
AP | 9.80 ± 1.79 | 5.20 ± 1.30* | 4.60 ± 1.52* | 3.60 ± 1.14* |
p-PI3K/ PI3K | 0.68 ± 0.15 | 0.97 ± 0.18* | 1.17 ± 0.19*# | 1.31 ± 0.10*# |
p-AKT/AKT | 0.57 ± 0.08 | 0.93 ± 0.07* | 1.11 ± 0.12*# | 1.62 ± 0.24*# |
p-mTOR/mTOR | 0.65 ± 0.13 | 1.47 ± 0.28* | 1.84 ± 0.13*# | 2.05 ± 0.42*# |