Fig. 2 | Scientific Reports

Fig. 2

From: Genomic profiling, implications for genotype-based treatment of 131 patients with phenylketonuria and characterization of novel p.Pro416Leu PAH variant

Fig. 2

Three-dimensional molecular model of the PAH protein. Close-up view of the region harboring p.Pro416 (a) and p.Leu416 (b) was analyzed using Dynamut2. Hydrophobic interactions are shown in green dotted lines, Van der Waals interactions are shown in blue dotted lines, polar interactions are shown in orange dotted lines and hydrogen bonds are shown in red dotted lines. In case of p.Leu416, novel interactions are formed: polar interactions with Gln419 and Thr418, additional hydrophobic interaction with Tyr414 and a hydrogen bond with Gln419.

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