Fig. 5

Difference analysis of gut microbial composition among Con, Anti and FMR. (A) Venn diagram depicting OTU richness and the overlap representing the shared OTUs in microbial communities. (B and D) Histogram of LEfSe analysis (LDA > 2.0, p < 0.05) showing the LDA scores for differentially abundant microbiota. (C and E) Correlation heatmap of significantly different microbiota and factors. The x- and y-axes are microbiota and factors, respectively. Co-efficient (R) in different colors is shown; the right side of the legend is the color range of different R values. cTn-I, Cardiac troponin I in serum; CK-MB, Creatine Kinase Isoenzyme-MB in serum; CD4⁺T, CD4⁺T lymphocytes in heart tissue; CD8⁺T, CD8⁺T lymphocytes in heart tissue; Th17, Th17 cells in heart tissue; CD25, CD25 mRNA in heart tissue; IL-10, Interleukin-10 mRNA in heart tissue; FOXP3, Forkhead box protein P3 mRNA in heart tissue; TGF-β, transforming growth factor β mRNA in heart tissue; IL-10(S), Interleukin-10 in serum; Tregs, CD25⁺FOXP3⁺Tregs in heart tissue. LEfSe: Linear discriminant analysis Effect Size; LDA: linear discriminant analysis; OUT: operational taxonomic unit. n = 6. *p < 0.05, **p < 0.01.