Fig. 3 | Scientific Reports

Fig. 3

From: Smooth muscle contractility of laser-enucleated prostate tissues and impacts of preoperative α1-blocker treatment in patients with and without catheterization

Fig. 3

EFS- and noradrenaline-induced contractions in tissues from surgery for BPH, and from radical prostatectomy for PCa. Frequency response curves for EFS (a) and concentration response curves for noradrenaline (b) were constructed in tissues from laser enucleation (HoLEP, ThuLEP) and TURP. Emax values were calculated by curve fitting, for EFS (a) and noradrenaline (b). Emax for RP tissues from are from control groups in our previous studies, published from 2018 to 2023. Accordingly, contractions with RP tissues were induced in the presence of different amounts of solvent (mostly DMSO), used in controls for drugs examined in these previous studies, whereas contractions with tissues from laser enucleation and TURP were induced without solvent. Data in frequency and concentration response curves are means with standard deviation (SD). Frequency and concentration response curves were compared by two-way ANOVA. Emax values from RP tissues were compared by one-way ANOVA with Dunn’s test to Emax values from laser-enucleated tissues (grey data sets: p < 0.05 vs. HoLEP/ThuLEP; see supplementary table 1 for details).

Back to article page