Fig. 5

Changes in YKL-40 expression cause changes in multiple genes and signaling pathways. (A) Volcano plot of differential mRNA expression determined using RNA-sequencing techniques. (B) Scatter plot of differential gene Kyoto Encyclopedia of Genes and Genomes enrichment55. (C–H) Selective hallmark gene sets showing the effects of YKL-40 were generated using the gene set enrichment analysis tool kit. Heat map showing the RNA expression levels (relative expression ratio compared with control) of differentially expressed genes were included in related gene set. YKL-40, chitinase 3 like 1.