Fig. 8 | Scientific Reports

Fig. 8

From: Immunogenicity and safety of CoronaVac vaccine in children and adolescents (Immunita-002, Brazil): A phase IV six-month follow up

Fig. 8

Kinetics of serum soluble mediators at one month (1 M), three months (3 M), and six months (6 M) after receiving two doses of CoronaVac in adolescents (12–17 years old) compared to the pre-vaccination period (Not Vaccinated—NV). The biomarkers were individually presented for chemokines (CXCL8, CCL11, CCL3, CCL4, CCL2, CCL5, and CXCL10); pro-inflammatory cytokines (IL-1β, IL-6, TNF-α, IL-12, IFN-γ, IL-15, IL-17); regulatory cytokines (IL-1Ra, IL-4, IL-5, IL-9, IL-10, and IL-13); and growth factors (FGF-basic, PDGF, VEGF, G-CSF, GM-CSF, IL-7, and IL-2). Statistical differences by Mann–Whitney and ANOVA with significance levels of p < 0.05 are denoted by (*) between groups.

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