Fig. 10 | Scientific Reports

Fig. 10

From: Integrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis

Fig. 10

Immunohistochemical(IHC) analysis for stromal cell metaplasia and the correlation between its α-SMA expression and DEPs ratio in adenomyosis. (A) Representative micrographs show the expression and localization of CD10, Caldesmon, α-SMA, and FN1 in the interstitial cells of adenomyotic tissue from patients. The red arrows indicate epithelial cells, while the blue ones indicate stromal cells. The red Star indicates the smooth muscle cells at the periphery of the stromal cells. Scale bars: 625 μm (up) and 100 μm (bottom), respectively. (B) Representative micrographs show the expression and localization of AKT and p-AKT in adenomyotic myometrium and normal myometrial tissue. Scale bars: 200 μm (up) and 100 μm (bottom), respectively. (C) Scatter plot of the extent of COL1A2, COL3A1, COL4A2, COL6A2, FN1, LTBP1, and LTBP4 expression difference ratio in fibrotic adenomyotic myometrium versus the α-SMA expression score in the myofibroblasts.

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