Fig. 1
From: Attenuated PINK1 autophosphorylation play neuroprotective and anti-seizure roles in neonatal hypoxia
Increased levels of phosphorylated PINK1/Parkin/Ub during hypoxia-induced seizures. (A-D) The increased levels of PINK1/P-PINK1 and Parkin/P-Parkin in the cortex and hippocampus (n = 4/group). (E-L) Immunohistochemistry staining of P-Ub (red) in the EC and DG (3 day). DAPI, blue. Bar = 50 μm. (M) Mean intensity of P-Ub immunostaining (n = 4/group). Mean ± SEM are presented. *P < 0.05, **P < 0.01, and ***P < 0.001, compared with controls (one-way ANOVA). C cortex; DG dentate gyrus; EC entorhinal cortex; H hippocampus; Hy Hypoxia; P-Parkin phosphorylated Parkin; P-PINK1 phosphorylated PTEN-induced kinase 1; P-Ub: phosphorylated ubiquitin.
