Fig. 6: Weight maps of tiles when predicting the point mutation status of RB1 and cell cycle pathway activity from mRNA expression data in liver cancer.

a Tumor tiles after data processing. b Weight map of tumor tiles in RB1 point mutation prediction. Brighter green tiles have larger weights. c Weight map in cell cycle pathway activity prediction. d, e Top 20 weighted tiles from RB1 point mutation prediction and cell cycle pathway prediction, respectively. We marked four tiles that appeared in both tasks. These tissues contain hepatocellular carcinoma with clear cell change from a pathologist’s perspective.