Fig. 3: Single-cell RNA-seq of human cells in cerebrospinal fluid.

A Robust rPCA representation of all single cells included in this study (n = 197) from 4 patients. Cells are colored by sample ID. B–D Expression of characteristic cell-type-specific genes overlaid on the robust rPCA plot (P < 2 × 10−16, t-test). E Cell-free CEACAM6 RNA level in CSF validated by qPCR. Results are shown as the mean ± standard deviation (SD) performed with three technical replicates.