Fig. 4: Validation of the novel KRT7 and progenitor-like PCa subtypes through immunohistochemistry staining.
From: Unveiling novel double-negative prostate cancer subtypes through single-cell RNA sequencing analysis
A The workflow chart illustrating the process of identifying KRT7 and progenitor-like patient samples in public cohorts. B–I Immunohistochemistry analysis demonstrated that KRT7 expression was exclusively detected in basal epithelial cells of benign prostatic hyperplasia (BPH) samples, whereas all deconvolution-identified samples of the KRT7 PCa subtype exhibited positive KRT7 protein staining. J–M Progenitor-like samples exhibited positive FOXA2 and SOX2 staining.
