Table 1 Correlation of CDH1 mutation to clinicopathological features of GC
Clinicopathologic feature | CARIS (N = 1596) | TCGA (N = 436) | |||||
---|---|---|---|---|---|---|---|
CDH1-MT (%) | CDH1-WT (%) | p | CDH1-MT (%) | CDH1-WT (%) | p | ||
Agea | Median | 57 | 64 | <0.001b | 60 | 68 | 0.01b |
(15–90) | (12–94) | (41–79) | (30–90) | ||||
Female | 55 | 64 | 0.002b | 58.5 | 69 | 0.073 | |
(27–90) | (12–94) | (41–78) | (34–90) | ||||
Male | 59.5 | 64 | 0.051 | 60 | 67 | 0.065 | |
(15–86) | (12–94) | (43–79) | (30–90) | ||||
Gender | Female | 73 (12.7) | 502 (87.3) | 0.0035b | 14 (9.0) | 144 (91.0) | 0.728 |
Male | 82 (8.0) | 939 (92.0) | 28 (10.0) | 251 (90.0) | |||
Type | Non-GEJ | 149 (12.4) | 1053 (87.6) | <0.001b | - | - | - |
GEJc | 6 (1.5) | 388 (98.5) | - | - | |||
Lauren subtyped | Diffuse | 33 (26.8) | 90 (73.2) | <0.001b | 18 (21.2) | 67 (78.8) | <0.001b |
Intestinal | 1 (1.4) | 72 (98.6) | 9 (4.7) | 181 (95.3) | |||
Mixed or unclear | 121 (8.6) | 1279 (91.4) | 15 (9.3) | 146 (90.7) |