Fig. 1: The mutational landscape of super MPLCs.

A Mutational landscape of nonsynonymous somatic mutations, including various alternation types like frameshift, deletions, and insertions. The columns represent samples, and there are 130 samples in total. Mutated genes are ordered by the mutation frequencies. Pathologic subtypes are annotated in the upper panel. AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IAC: invasive adenocarcinoma. B Comparison of the mutation frequencies of several driver genes among our PUMCH-ssesMPLC cohort, two cohorts of MPLC with fewer lesions, and an early-stage single-lesion lung cancer cohort. C Functional enrichment analyses on mutated genes. D Co-occurrence or exclusivity of high-frequency mutations. We include mutations occurring in no fewer than 5 samples. The dot plot displays the odds ratios (OR) (Fisher’s exact test) of exclusivity (red) and co-occurrence (blue). The size of the dots also represents the logarithm of the odds ratios. The value of log (OR) is assigned 1 when the OR ratio is positive infinity (since no samples had a common mutation of the two genes). The significances (asterisks) are calculated by the DISCOVER method⁵⁶. (*** < 0.001; ** < 0.01; * < 0.05).