Biocatalysis needs improved reproducibility and quality of research reporting. Our interdisciplinary team has developed a flexible and extensible metadata catalogue based on STRENDA guidelines, essential for describing complex experimental setups in biocatalysis. The catalogue is available online via GitHub for community use.
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Acknowledgements
The authors thank the European Research Council (ERC) for funding parts of this work with the ERC starting grant 757320 “Light Controlled Synthetic Enzyme Cascades” as well as the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) for funding under Germany’s Excellence Strategy (Exzellenzcluster 2186 “The Fuel Science Center” ID 390919832 and Exzellenzcluster 2075 "Data-Integrated Simulation Science" ID 390740016). We also acknowledge the support of the ERC under Advanced Grant Number 101021024. This research was conducted as part of the project “Understanding the Effect of Non-natural Fluid Environments on Enzyme Stability”. The Beilstein-Institut supports the STRENDA Commission. P.W. and B.N. thank TU Graz Lead Project PorousMaterials@Work for support. The success of this research is a testament to the collective efforts of the team and the supportive research community. We acknowledge the contributions of our colleagues and collaborators, who have enriched the scientific discourse and outcomes of this study.
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S.M. conceived the idea, designed the research project, organized the catalogue structure, collected metadata, wrote the first draft of the manuscript and coordinated meetings. D.M. designed the catalogue, co-wrote the manuscript and coordinated meetings. J.R. provided technical support, including sdRDM, GitHub pages and coding. Z.F.B., K.R., P.W., J.M.W. and P.J.H. contributed expert knowledge in biocatalysis, added content to specific subtopics, and commented on the catalogue and manuscript. R.W., B.N. and R.T.G. provided expert input and commented on both the catalogue and manuscript. K.P., P.C., A.S.B., J.M.R. and R.O.M.A.d.S. commented on and carefully revised the catalogue and manuscript. J.P. and C.K. made substantial contributions by improving and refining the metadata catalogue and final manuscript. D.R. conceived, designed and supervised the project, provided expert knowledge in biocatalysis, assisted with writing the first draft, and coordinated meetings. All authors contributed their subject-specific knowledge, reviewed the manuscript, participated in regular meetings to develop the guidelines and discuss the architecture and approved the final version of the manuscript.
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Nature Catalysis thanks the anonymous reviewers for their contribution to the peer review of this work.
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Malzacher, S., Meißner, D., Range, J. et al. The STRENDA Biocatalysis Guidelines for cataloguing metadata. Nat Catal 7, 1245–1249 (2024). https://doi.org/10.1038/s41929-024-01261-x
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DOI: https://doi.org/10.1038/s41929-024-01261-x