Extended Data Fig. 3: Pathway enrichment analysis of genetic interactions for fatty acid synthesis-related query genes in additional HumanCyc sub-categories. | Nature Metabolism

Extended Data Fig. 3: Pathway enrichment analysis of genetic interactions for fatty acid synthesis-related query genes in additional HumanCyc sub-categories.

From: Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Extended Data Fig. 3

a, Dot plot of normalized pathway enrichment values for aggregate GIs across the six query genes (FASN, C12orf49, LDLR, SREBF2, ACACA, SREBF1) with sub-categories from HumanCyc are indicated. A GI is identified for a query-library pair if the |qGI| > 0.5 and FDR < 0.5. Enrichment for positive (yellow) and negative (blue) GI is tested inside Glycan Pathways and Generation of precursor metabolite and energy HumanCyc branches using a hypergeometric test. Enrichment with p-value < 0.05 are blue (negative GI) and yellow (positive GI). Dot size is proportional to the fold-enrichment in the indicated categories and specified in the legend.

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