Extended Data Fig. 10: MT1-MMP deletion in GFRAL neurons abolishes obese-induced downregulation of GFRAL.
From: Body weight regulation via MT1-MMP-mediated cleavage of GFRAL
(a) Immunostaining of GFRAL in the brainstems from Mmp14f/fGfralcre+ mice on high fat diet and Mmp14f/+Gfralcre- on standard or high fat diet. (scale: 20μm) (b) Quantification of the relative fluorescence intensity of GFRAL staining in (a). (n=6) (c) qPCR analyses of Gfral expression in the AP from Mmp14f/fGfralcre+ mice on high fat diet and Mmp14f/+Gfralcre- on standard or high fat diet. (n=6) Data are reported as average ± s.e.m. one-way ANOVA.
