Extended Data Fig. 4: The gut microbiota profile between the anti-PD-1 group and the anti-PD-1+acarbose group.
a, Dominant phyla and their contribution to each group: a visual circle diagram describing the correspondence between samples and phylum (n = 5 per group). b, A Manhattan plot showing the distribution of differential OTUs between anti-PD-1 group and acarbose+anti-PD-1 group (n = 5 per group). OTUs were arranged at the phylum level and coloured according to the phylum. c, Ranking of differentially abundant taxa at the genus level by importance to the gut microbial community, as determined by their MDA using the unsupervised RandomForest analysis. MDA: mean decrease in accuracy, higher MDA indicated greater importance. Differential taxa were determined using R package “limma”. P values were adjusted using the Beniamini and Hochberg’s approach for controlling the false discovery rate (b,c).
