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Viewing MASLD through an integrative gut microbiome lens

Nature Metabolism (2025)Cite this article

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The gut microbiome is pivotal to the development of liver diseases in multifaceted ways. A recent study uses a multi-omics, multi-kingdom approach to analyse the gut dysbiosis in metabolic dysfunction-associated steatotic liver disease, highlighting a substantial role for oral-typical microorganisms and their associated metabolites.

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Fig. 1: The multi-omic and multi-kingdom features of the gut microbiome in MASLD.

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Authors and Affiliations

  1. Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    Weijie Wen & Tao Zuo

  2. Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou, China

    Weijie Wen & Tao Zuo

  3. Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    Weijie Wen & Tao Zuo

  4. Department of Gastroenterology and Hepatology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China

    Changqing Yang

Authors
  1. Weijie Wen
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  2. Changqing Yang
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  3. Tao Zuo
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Correspondence to Tao Zuo.

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Wen, W., Yang, C. & Zuo, T. Viewing MASLD through an integrative gut microbiome lens. Nat Metab (2025). https://doi.org/10.1038/s42255-025-01300-2

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