Extended Data Fig. 8: Invasive and metastatic features of gastric cancer EPO-GEMMs.
From: Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
(a) H&E images showing the boundary (dashed lines) between normal stomach and gastric tumors with areas of local invasion (arrows) in C57BL/6 EPO-GEMMs with MYC-p53−/− (left) and MYC-Apc−/− (right). Representative image of n = 3 mice. (b) Petal plot of metastasis incidence in the specified organs of MYC-Cdh1 EPO-GEMMs. The radius of each petal corresponds to the fraction of mice developing metastases in the indicated organ; the outermost ring corresponds to 100% (n = 6 independent mice). (c) Macroscopic (left) and H&E histology image (right) of liver metastasis in mice subjected to tail vein injection of a MYC-Apc−/− gastric cancer cell line. Images are representative of 3 metastasis-bearing livers from 10 mice analyzed. (d) Incidence of liver and lung metastases among the MSK-MET cohort of gastric cancer patients with WNT pathway mutations or TP53 mutations. Statistical analysis as reported42. (e) Macroscopic (left) and H&E histology image (right) of ovarian metastasis in mice subjected to tail vein injection of MYC-p53−/− gastric cancer cell lines. Images are representative of one metastasis-bearing ovary from 10 mice analyzed for each of three independent cell lines.
