Fig. 5: Gastric cancer EPO-GEMMs display metastatic patterns that recapitulate the human disease.
From: Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
a–e, Representative gross pathology images of liver (a), lungs (b) and peritoneal metastases at the diaphragm (c), body wall (d) and abdomen (e) from MYC-p53−/− gastric cancer EPO-GEMMs. Arrows point to macroscopic tumors. f–i, Representative H&E-stained histological images of liver (f), lung (g) and peritoneal (h,i) metastases from MYC-p53−/− gastric cancer EPO-GEMMs. j,k, Representative macroscopic (j) and H&E-stained histological (k) images of an adrenal metastasis from MYC-p53−/−-Msh2−/− gastric cancer EPO-GEMMs. l–n, Petal plots of metastasis incidence in the specified organs of EPO-GEMMs harboring the indicated genotypes. The radius of each petal corresponds to the fraction of mice developing metastases (mets) in the indicated organ; the outermost ring corresponds to 100% (n = 9–10 independent mice). Detailed numbers are provided in the statistical source data. o–q, Incidence of liver (o), lung (p) or peritoneal metastasis (q) in EPO-GEMMs and in the MSK-IMPACT cohort of patients with esophagogastric cancer with the corresponding genetic alterations. The exact number of independently analyzed tumors is indicated. Statistical analysis by Fisher’s exact test. r–s, Representative macroscopic (r) and H&E-stained histological (s) images of an ovarian metastasis from a MYC-p53−/− gastric cancer EPO-GEMM.
