Extended Data Fig. 9: Human pan-cancer analysis. Related to Fig. 6.

(a) Boxplots of the fraction of CD8+ cells active for the breast cancer manifold programs across patients’ tumor samples from different cancer types in the pan-cancer atlas. (b) Boxplots of the fraction of CD8+ cells active for the breast cancer manifold programs across patients’ blood (periphery) samples from the pan-cancer atlas. (c) Heatmap showing the Pearson correlation of the fraction of cells active for the breast cancer manifold programs to the original cell state annotation across patients from the pan-cancer atlas. (d) Scatter plot (top) of the programs score (X) to the mutational burden score (Y), with each dot representing a patient colored by cancer type. Statistics are based on Spearman correlation test. The bar plot (bottom) shows the Pearson correlation of individual programs to the mutational burden score across patients.