Extended Data Fig. 8: Integration of bulk-derived mutation calls with single-cell-derived tumor phenotype. | Nature Cancer

Extended Data Fig. 8: Integration of bulk-derived mutation calls with single-cell-derived tumor phenotype.

From: A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia

Extended Data Fig. 8

(a) Recurrently mutated genes seen in low-risk T-specified >50% patients. (b) Recurrently mutated genes seen in high-risk BMP-like > 25% patients. (c) Driver fusion profile of high BMP-like patients (high risk, left) and high T-specified patients (low risk, right). (d-e) Prognostic value of individual mutated genes associated with BMP-like (d) and T-specified states (e). The p-value for two-sided t-test is shown above each boxplot; the p-value for Log-likelihood statistic of Cox-proportional hazard test run with Day 29 MRD as a healthy donorier curves. (f) NOTCH1 signature scores for T-specified and BMP-like blasts. Pathways were obtained from the Molecular Signatures Database or as published by Wang et al. and Wilkins et al. Significance was assessed using a two-sided Wilcoxon rank-sum test.

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