Fig. 8: scRNA-seq characterizes the microglial crosstalk with OPCs and OLs in control and 3xDR brains. | Nature Aging

Fig. 8: scRNA-seq characterizes the microglial crosstalk with OPCs and OLs in control and 3xDR brains.

From: Transcriptional and epigenetic decoding of the microglial aging process

Fig. 8

a, Scheme of the forced microglial turnover model and timepoints for experiments. Control mice are sex-matched and age-matched animals fed with CD for 130 d. b, tSNE plots of 11,952 control and 8,914 3xDR microglia, revealing an aged-like phenotype of 3xDR microglia. c, Dot plot showing the expression levels of well-known representative cell-type-enriched marker genes across all 16 cell types (18 populations). d, Significant ligand–receptor interactions predicted by CellPhoneDB. One-sided permutation test. e, Significant molecule–molecule interactions predicted by CellChat. One-sided permutation test. Hb-VC, hemoglobin-expressing vascular cell; ImmNeuron, immature neuron; mNeuron, mature neuron; NendC, neuroendocrine cell; OEG, olfactory ensheathing glia; VLMC, vascular and leptomeningeal cell; VSMC, vascular smooth muscle cell.

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