Extended Data Fig. 1: Sex differences in the microglial transcriptome at each age.
From: Transcriptional and epigenetic decoding of the microglial aging process
(a) PCA plots display the sex differences in the microglial transcriptome at 3, 9, 16 and 24 months of age. (b) Numbers of differentially expressed genes at each age (left) and numbers of differentially expressed genes with higher expression in females or males (right). (c) Volcano plots of male vs. female microglial transcriptome changes at each age. Red points indicate DEGs. Log2FC ≥ Log21.5, P < 0.05, quasi-likelihood (QL) F tests. (d) Top 20 enriched BP annotations by GO of the male vs. female microglial DEG profile at each age. Q < 0.05. Accumulative hypergeometric test with false discovery rate (FDR) correction. Dim, dimension.
