Extended Data Fig. 8: Human atherosclerotic plaque CD8 T cells express GZMK and associate with symptomatic atherosclerotic disease. | Nature Aging

Extended Data Fig. 8: Human atherosclerotic plaque CD8 T cells express GZMK and associate with symptomatic atherosclerotic disease.

From: Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice

Extended Data Fig. 8

(a) UMAP plot of T cells from human atherosclerotic plaques from public study deposited to Zenodo: 3361716. (b) GZMK expression overlayed on UMAP plot of T cells in human atherosclerotic plaques with dashed line indicating cells with the highest GZMK expression. (c) top 15 differentially expressed genes in the CD8+ T cell cluster. (d) Violin plot of GZMK expression on 3 T cell clusters, stratified by symptomatic group. For D, two-tailed Venice non-parametric benchmarking method within BBrowser3 was used to compare groups (see Methods) and data represents mean with lines above and below representing 1st and 3rd quartiles. Raw data for this figure is from a publicly available dataset archived on Zenodo: 3361716. UMAP = uniform manifold approximation projection.

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