Fig. 5: CD38 deletion rescued aging-related changes in core regulatory TFs and ligand–receptor interactions between different cell types.

a–c, Rose diagrams showing the numbers of changes of TFs with aging (a, aging TFs), CD38 deletion (b, Cd38^−/− TFs) and rescued TFs after CD38 deletion (c, rescued TFs) in the six cell types. d,e, Visualization of CD38 deletion downregulated (d) and upregulated (e) rescued TFs in the network. The internal nodes represent TFs, with gray circular edges indicating downstream target DEGs influenced by these TFs. Node sizes are proportional to the number of associated DEGs. The rescued TFs are shown in red. f, Network diagrams illustrate alterations in ligand–receptor interaction events across distinct cell types in the ovaries of 2-month-old and 12-month-old WT mice (left), as well as in 12-month-old Cd38^−/− and WT mice (right). Cell–cell communication is represented by interconnected lines, with line thickness reflecting a positive correlation with the quantity of ligand–receptor interaction events. g, GO enrichment of rescued (left) and erased (right) interaction pairs in each cell type.