Table 2 C-statistics and 95% CIs of sex-stratified Cox regression models for PRSs, gut microbiome scores and conventional risk factors
From: Integration of polygenic and gut metagenomic risk prediction for common diseases
Model | Age | Age + PRS | Age + microbiome score | Age + PRS + microbiome score | CRFs | CRFs + PRS + microbiome score |
|---|---|---|---|---|---|---|
Disease | C-statistic (95% CI) | |||||
CAD | 0.719 (0.695–0.743) | 0.766 (0.742–0.789) | 0.722 (0.698–0.747) | 0.767 (0.744–0.791) | 0.771 (0.748–0.793) | 0.794 (0.772–0.817) |
T2D | 0.625 (0.605–0.646) | 0.675 (0.654–0.695) | 0.665 (0.644–0.685) | 0.702 (0.681–0.722) | 0.785 (0.768–0.802) | 0.799 (0.783–0.816) |
AD | 0.880 (0.864–0.895) | 0.898 (0.883–0.914) | 0.880 (0.864–0.895) | 0.898 (0.883–0.914) | 0.883 (0.868–0.899) | 0.900 (0.885–0.915) |
Prostate cancer | 0.769 (0.739–0.798) | 0.797 (0.766–0.828) | 0.774 (0.745–0.802) | 0.801 (0.770–0.832) | 0.773 (0.744–0.802) | 0.804 (0.774–0.834) |
