Extended Data Fig. 3: Human intervention lipidome with and without randomization scheme in statistical analysis.
From: A conserved complex lipid signature marks human muscle aging and responds to short-term exercise
Assessment of the human intervention lipidome at the lipid class level, both without (x axis) and with (y axis) taking into account the order in which the participants underwent a regimen. Scatterplots compare the fold changes (log2 scale) of a, exercise vs sit, b, sitless vs sit, and c, exercise vs sitless derived from both statistical comparisons (where significance was determined using an empirical Bayes moderated t-test, two sided). High Pearson’s correlations observed between both statistical approaches (>0.9) and significance values (p < e-10) indicates that the order in which a participant underwent an intervention did not greatly impact the lipidomics analyses. For Source Data file see Supplementary Data Table 7.
