Fig. 4: T-ALL subset epigenetic age estimation.
From: Conserved epigenetic hallmarks of T cell aging during immunity and malignancy
a,b, Summary graphs of patient chronologic age (a) versus estimated tumor age (b) based on T-ALL subset using the Horvath epigenetic clock (n = 13–31 in the UTokyo cohort and n = 4–28 in the St. Jude cohort). The P values are based on a two-sided Student’s t-test. c, Summary box plots for the T-ALL patient tumor genome-wide DNA methylation levels versus EA programs among three independent cohorts (GRAALL n = 143, St. Jude/ECOG n = 48 and UTokyo n = 98). The P value is based on a two-sided Student’s t-test. d, DNA methylation level heatmap of ML EA programs for St. Jude/ECOG T-ALL patients. e, Summary graph of ML EA programs among established T-ALL patient subtypes. The P values are based on two-sided Student’s t-tests comparing HOXA and TAL1 subtypes (n = 13–31 in the UTokyo cohort and n = 4–28 in the St. Jude cohort. For all box plots, the box and hinges correspond to the first, second and third quartiles, the upper whisker extends to the minimum (largest value, upper hinge + 1.5 × interquartile range) and the lower whisker extends to the maximum (smallest value, lower hinge − 1.5 × interquartile range).
