Extended Data Fig. 1: Transcriptomic and epigenetic profiles of multi-lifetime memory T cells at genes of interest. | Nature Aging

Extended Data Fig. 1: Transcriptomic and epigenetic profiles of multi-lifetime memory T cells at genes of interest.

From: Conserved epigenetic hallmarks of T cell aging during immunity and malignancy

Extended Data Fig. 1

(a) DNA methylation level plots and ATAC seq tracks of genes associated with T cell stemness among multi-lifetime memory T cells. (b) Methylation level plots and ATAC seq tracks of genes associated with effector T cell functions among multi-lifetime memory T cells. (c) Methylation level plots and ATAC seq tracks of inhibitory receptor genes among multi-lifetime memory T cells. (d) Summary graphs for RNAseq transcript levels corresponding to genes in the methylation and ATACseq plots. n = 3 biologically independent samples. (e) Heatmap showing relative transcript abundance for cell-cycle regulators with measurable transcript defined from the ML memory T cell model. (f) Representative CpG DNA methylation of Ebf3 and Irx2 loci among top EA-associated DMRs from the multi-lifetime memory CD8 T cells.

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