Extended Data Fig. 4: Effect of CD38 on Ca2+ signaling and mitochondrial activity under homeostatic condition.
From: An NAD+-dependent metabolic checkpoint regulates hematopoietic stem cell activation and aging
a-h. Comparison of enriched HSCs derived from 3-month-old WT and CD38 KO mice. A, B. Representative histograms (A) and quantification (p = 0.3041) (B) for Fluo-4 staining analyzed via flow cytometry. MFI, mean fluorescence intensity. n = 6. c, d. Representative histograms (C) and quantification (D) for Rhod-2 staining analyzed via flow cytometry (p = 0.2955). n = 6. e, f. Representative histograms (E) and quantification (F) for ROS staining analyzed via flow cytometry (p = 0.3350). n = 6. g, h. Representative histograms (G) and quantification (H) for TMRM staining analyzed via flow cytometry (p = 0.1819). n = 6. Data are presented as mean values +/- SE. ns: p > 0.05. One-sided student’s t test.
