Extended Data Fig. 5: PGF2α sustains lymphatic drainage into cervical lymph nodes.
From: Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage
(a) CSF clearance was evaluated via an intracisternal injection of ovalbumin-conjugated to Alexa 647 (OVA- Alexa 647) with or without PGF2α in young and old mice. After 90 min sLN and dLN were dissected and taken imaging under microscope. (b) Representative images of the ex vivo lymph nodes with or without PGF2α administration in young and old mice group. Scale bar = 2 mm. Fluorescent mean pixel intensity (MPI) normalized by the area of lymph nodes for sLN (c) and dLN (d). one-way ANOVA with post hoc Tukey’s test. Data are presented as mean ± SEM; n = 4 mice/group.
