Fig. 3: Aging endometrium shows genome-wide PGR depletion.
From: Endometrial aging is accompanied by H3K27ac and PGR loss
a, Heatmaps of the PGR signal in human mid-secretory endometrial stromal cells at PGR peaks in the young group. b, Volcano plot illustrating PGR differences between young and aging mid-secretory endometrial stromal cells. Red and blue points represent peaks that gain and lose the PGR signal in aging stromal cells. c, The genomic distribution of PGR peaks in human mid-secretory endometrial stromal cells. d, GO enrichment analysis of genes with PGR depletion in aging mid-secretory endometrial stromal cells. e, KEGG enrichment analysis of genes with PGR depletion in aging mid-secretory endometrial stromal cells. f, Venn diagram illustrating the overlap between downregulated DEGs and genes with PGR depletion in aging mid-secretory endometrial stromal cells. g, Pathway enrichment analysis of 708 common genes indicated in f. h, The PGR signal in mid-secretory endometrial stromal cells at selected genes. hg38 coordinates are shown. The blue shading indicates the specific region with PGR depletion in the middle-aged group. i, FPKM of selected genes in human mid-secretory endometrial stromal cells (n = 4). The adjusted P value was determined by DESeq2 (ref. 79). Data are presented as mean ± s.d. All replicates were biological replicates. FC, fold change; FPKM, fragments per kilobase of transcript per million mapped reads; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; mid-aged, middle-aged; P.adj, adjusted P value; UTR, untranslated region.
